Protein Modeling and
Sequence Analysis

Experimental structure determination involves difficult methods that require a significant amount of expertise and resources, and can take years to yield results. Protein Modeling on the other hand enables access to sensible structural models within a matter of hours or even minutes. Template based modeling has been shown to yield useful models in countless publications. As more and more experimental structures become available, the greater the scope template based Protein Modeling will provide researchers with accurate models quickly and efficiently.

Protein Modeling and Sequence Analysis solutions in Discovery Studio provide the necessary set of tools for the construction of molecular structures, as well as macromolecular docking, in an easy to use customizable graphical user interface suitable for novice and expert users.

Protein Modeling and Sequence Analysis in
Discovery Studio 2.0 includes:

• Access to BLAST and PSI-BLAST algorithms to search for homologs using sequence similarity
• Automated CDR identification and annotation for antibody modeling
• Renowned algorithms for the generation of high quality homology models
• Advanced methods to optimize and validate protein models
• The fastest and most accurate algorithms, ZDOCK and RDOCK, for protein-protien docking
• Macromolecular pK prediction based on the G-Born model for charge distribution