Homology & Antibody Modeling Software and Services

Short of having an experimentally characterized structure of the protein, the next best thing is having the three dimensional characterization of a protein from its amino acid sequence and a known set of related proteins. This structure can help with understanding the types of interactions between the protein and its ligands (whether the native ligand or a small molecule inhibitor that prevents the native ligand from interacting with the protein). Antibody modeling is a natural extension of these approaches as applied to the specific system.

Related Product and Services:

• Discovery Studio Protein Modeling and Sequence Analysis Software:
  • MODELER - enables prediction of the 3D structure of the protein and characterization of its binding site; guides antibody design experiments; provides an understanding of how antibodies interact with antigens (or other molecules).
  • Protein Health - can test the validity of a protein structure (full or partial) derived from modeling studies or experimental methods
  • Protein Refine - protein models can then be further refined using the well-established CHARMm engine
• Contract Research & Scientific Consulting Services - team up Accelrys' drug discovery service team who has expertise in our full suite of software for homology and antibody modeling