High Content Analysis

Uncover the true value of your high content analysis data by seamlessly integrating it with numerical, chemical, biological and textual data from across your workflow and organization. Accelrys' SciTegic Platform provides a web-based computing framework for visually creating custom data processing and analysis workflows that can span the entire HCA process. HCA workflows built on the SciTegic platform can be used to access data from libraries used in the screen, images, numerical data, lab notebook data, and even Excel files containing experiment design and notes. A range of configurable components to be used to create custom image processing workflows for HCA data in which you can:

• quickly QC many plates and many features at one time
• calculate QC statistics (z score etc. ) and reports on the fly
• include results from many devices (and vendors) at one time
• visualize complex statistical metrics in a simple and interactive format
• export to Spotfire, Partek, Excel, LabView, JMP, etc.
• easily incorporate 3rd party software applications
• apply automated business rules across each cell, well, plate or screen
• transform and update curve fits on the fly
• create custom interactive reports unparalleled in any HCA vendor software systems

Additional benefits of creating an HCA solutions with Accelrys technology include:

• Supplemental analysis collections - A wealth of compatible analysis collections in the areas of chemistry, sequence analysis, R-statistics, data modeling, and reporting make it possible to create robust HCA workflows.
• Instrument agnostic design - The platform comes with readers for a variety of image file formats, as well as parsers for image analysis data files from many major HCA vendors.
• Automation capabilities - You can save weeks of image review time by automatically processing and presenting only images that meet user-defined criteria, while archiving the rest. This can be an invaluable feature given that a single well plate will contain on average 1000 images, resulting in a screen that may contain upwards of 100,000 images.
• Custom management - Manage images and associated data through new or existing ODBC complaint solutions.
• Data quality control and transformation - Take advantage of customized and flexible tools for automated advanced statistical analysis and data transforms. For example, users have been written to interface with the several HCS data systems. Web-based heat maps can displayed, permitting scientists to interact with the data and perform QC. Wells can be marked as outliers and the plate marked for re-scan and re-analysis by vendor software. Users can quickly move among plates to rapidly QC their data. Existing end users have reporting up to ten-fold productivity. QC statistics and reports can be calculated on the fly.

Related Software and Services:

• Imaging Collection for the SciTegic Platform - this intuitive, web-based, enterprise-accessible software platform provides sophisticated tools for enhancing, processing, analyzing, measuring, and reporting image data, while also enabling integration of image data with numerical, chemical, graphical and textual data
• Advanced Imaging Collection for the SciTegic Platform - well suited for nearly any imaging application, the Advanced Imaging Collection offers enhanced image processing and analysis functionality, such as tools for altering morphology, processing sequences and stacks, and transforming, clustering and segmenting image data; in addition to supporting all the industry-standard imaging formats, the Advanced Collection also includes image, measurement and metadata readers for DICOM and HCS vendor specific file formats
• Chemistry Collection for the SciTegic Platform -offers a comprehensive suite of molecular property calculators, filters, and manipulators.rm
• Sequence Analysis Collection for SciTegic Pipeline Pilot - provides tools for analyzing biological sequences
• R Statistics Collection for SciTegic Pipeline Pilot - perform data manipulation, clustering, learning, and data analysis with tools based on the R statistics package
• Modeling Collection for the SciTegic Platform - a comprehensive suite of learning and data modeling tools, statistical filters, and clustering components optimized for large data sets
• Integration Collection for the SciTegic Platform - offers numerous flexible mechanisms for seamlessly linking external applications and databases on the SciTegic platform
• Reporting Collection for the SciTegic Platform - With the capability to link chemistry, image and assay design components in one plate map, Accelrys' HCA solutions enable the creation of custom interactive reports and dashboards unparalleled in any HCA vendor software systems
• Accelrys Solutions Consulting Group - The Accelrys Solutions Consulting has a wealth of expertise in HCA solutions. For example, you can enlist the team to help integrate with HCA system from various vendors. Integrations has been been performed for a variety of popular systems (Cellomics ArrayScan, Evotec Opera, GE InCell , Beckman Coulter IC100, BD Pathway, Blueshift). Or, turn to the Accelrys Solutions Consulting team to help create custom HCA reporting portals.